Neuroscientists from the Department of Psychology in the College of Arts and Sciences and the Department of Behavioral Science in the College of Medicine have received an award from the National Institutes of Health to study cocaine use disorder from a new perspective.

Cocaine use disorder (CUD) is marked by the repeated decision to pursue and use cocaine over other available activities and goods. However, lab-based studies to date have not systematically investigated the decision-making processes that underlie the choice to use cocaine. The present translational, multidisciplinary project melds modern mathematical modeling techniques with state-of-the-art neuroscience methods to investigate the neurobehavioral processes that underlie cocaine-associated decision-making in real time. This innovative approach enables the simultaneous quantitative characterization of cocaine-associated decision dynamics and governing neural processes, all directed toward uncovering the mechanisms of maladaptive choice in CUD and identification of novel treatment targets.

This research is funded by the National Institute on Drug Abuse, www.drugabuse.gov